Cytochalasin D, MP Biomedicals™

Description

Disrupts actin filaments and inhibits actin polymerization. Cytochalasin D, MP Biomedicals is a cell-permeable fungal toxin that binds to the barbed end of actin filaments, inhibiting both the association and dissociation of subunits. It possesses antibio

This compound disrupts actin microfilaments and activates the p53-dependent pathways, causing arrest of the cell cycle at the G1-S transition.

• Inhibits smooth muscle contraction
• Inhibits insulin-stimulated, but not basal, transport of glucose
• Possesses antibiotic and antitumor activity
• Impairs maintenance of long term potentiation (LTP) of actin filaments
• Implicated in promoting conditions favorable for depolymerizing actin

Specifications

Chemical Identifiers

• CAS: 22144-77-0
• Molecular Formula: C30H37NO6
• Molecular Weight (g/mol): 507.627
• InChI Key: SDZRWUKZFQQKKV-DKLHZCHASA-N
• Synonym: cytochalasin d
• PubChem CID: 131668624
• SMILES: CC1CC=CC2C(C(=C)C(C3C2(C(C=CC(C1=O)(C)O)OC(=O)C)C(=O)NC3CC4=CC=CC=C4)C)O

• Melting Point: 193°C to 195°C (literature)
• Quantity: 10 mg
• Solubility Information: Soluble in chloroform (10g/mL, clear, colorless solution), CH2Cl2 (10mg/ mL, clear colorless solution), DMSO and ethanol.
• Formula Weight: 507.6
• Physical Form: Powder

Safety and Handling

Recommended Storage

Store at −20°C, protect from light, dessicated.

WARNING: Reproductive Harm - www.P65Warnings.ca.gov