Cytochrome C, MP Biomedicals™

Description

Regarded as a universal catalyst of respiration, forming an essential electron-bridge between the respirable substrates and oxygen. Cytochrome C, MP Biomedicals is an electron-carrying mitochondrial protein that plays a vital role in cellular oxidations i

The transition of Cytochrome C between the ferrous and ferric states within the cell makes it an efficient biological electron-transporter.

• It has been identified as an important mediator in apoptotic pathways.The release of mitochondrial Cytochrome C into the cytoplasm stimulates apoptosis and is commonly used as an indicator of the apoptotic process in the cell.
• Investigation on the effect of Paris saponin I (PS I) on human gastric carcinoma cell growth (SGC7901 cells) have shown an elevated level cytoplasmic cytochrome c. Results are an inhibition of proliferation in SGC7901 cells by inducing mitochondria-dependent apoptosis through Cytochrome C.
• The specific sites and extent of oxidation in horse Cytochrome C treated with H2O2 and UV were characterized. It was suggested that the state of these sites could be used as a biomarker for the oxidative environment in a cell.

Specifications

Chemical Identifiers

• CAS: 9007-43-6
• Molecular Formula: C40H48FeN6O6S4
• Molecular Weight (g/mol): 892.94
• MDL Number: MFCD00130890
• InChI Key: UMUOLVQYJUIZKD-RHANTFMNSA-L
• Synonym: cytochrome c, 3-7,12-bis 1-2-amino-3-methylamino-3-oxopropyl sulfanylethyl-18-2-carboxyethyl-3,8,13,17-tetramethylporphyrin-21,23-diid-2-yl propanoic acid; iron 2+
• PubChem CID: 16057918
• SMILES: CC(SC(=O)[C@@H](N)CS)C1=C(C)\C2=C\C3=C(C(C)SC(=O)[C@@H](N)CS)C(C)=C4CC5N=C(\C=C6/N([Fe++]N34)\C(=C/C1=N2)C(C)=C6CCC(O)=O)C(CCC(O)=O)=C5C

• Quantity: 100 mg
• Solubility Information: Dark red to Red-Brown Solution at 10mg plus 1mL of water.
• IUPAC Name: 3-[8,13-bis[1-[2-amino-3-(methylamino)-3-oxopropyl]sulfanylethyl]-18-(2-carboxyethyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;iron(2+)
• Formula Weight: ∼12,000
• Percent Purity: ≥90%
• Physical Form: Powder

Safety and Handling

Recommended Storage

−20°C