Medchemexpress LLC CZC-8004 | 916603-07-1 | 99.8% | 309.34 | 25 MG

Supplier:  Medchemexpress LLC 25MGHY111138

CZC-8004, also known as CZC-00008004, is a pan-kinase inhibitor that exhibits inhibitory activity against both wild-type Epidermal Growth Factor Receptor (EGFR WT) and Vascular Endothelial Growth Factor Receptor 2 with a V916M mutation (VEGFR2 V916M). This compound has been investigated for its potential in cancer studies, with reported IC50 values of 650 nM and 437 nM for EGFR WT and VEGFR2 V916M, respectively. It has shown selective targeting capabilities in certain human cancer cell lines, such as H1975 cells with the VEGFR2 V916M mutation.

• Pan-kinase inhibitor.
• Specific IC50 values: Demonstrates inhibitory action against EGFR WT (650 nM) and VEGFR2 V916M (437 nM).
• Cancer research potential.
• Targeting ability in specific cell lines: Shows activity against H1975 cells with VEGFR2 V916M mutation.

Catalog No. 50-003-45548