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Medchemexpress LLC D-64131 | 74588-78-6 | C16H13NO2 | 100 MG
Supplier: Medchemexpress LLC HY15482100MG
D-64131 is an orally active tubulin inhibitor with an IC50 of 0.53 μM for tubulin polymerization. It exhibits antimitotic activity and can be utilized for cancer research. It is antimitotic by binding to β-tubulin, destabilizing microtubules, and arresting mitotic cells in the M-phase. This compound inhibits the proliferation of tumor cells from various organs and tissues, including cytotoxicity against MDR/MRP tumor cell lines.
- Exhibits antimitotic activity
- Useful in cancer research
- Inhibits tumor cell proliferation
- Cytotoxic against MDR/MRP tumor cell lines
- Suppresses U373 proliferation and cell cycle
- Significantly inhibits tumor growth in human amelanoic melanoma xenograft models
- Possesses oral bioavailability
- Well tolerated at efficacious doses
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