Medchemexpress LLC D-64131 | 74588-78-6 | C16H13NO2 | 5 MG

Supplier:  Medchemexpress LLC HY154825MG

D-64131 is an orally active tubulin inhibitor with an IC50 of 0.53 μM for tubulin polymerization. It has antimitotic activity and can be used for cancer research. It is antimitotic by binding to β-tubulin, which destabilizes microtubules and arrests mitotic cells in the M-phase. It inhibits the proliferation of tumor cells from 12 of 14 different organs and tissues with mean IC50s of 62 nM. It is also cytotoxic towards MDR/MRP tumor cell lines. In vivo studies have shown that D-64131 significantly inhibits tumor growth in human amelanoic melanoma MEXF 989 tumor xenograft mice models and exhibits oral bioavailability, being well tolerated at efficacious doses.

• Orally active tubulin inhibitor
• Potent antimitotic activity
• Broad-spectrum anti-tumor activity
• Cytotoxic to drug-resistant cell lines
• Well-tolerated in vivo
• Research use only
• High purity

Catalog No. 50-003-76931