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Medchemexpress LLC [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-substance P | 96736-12-8 | MFCD00076802 | 98.5% | 1,516.83 g/mol | C79H109N19O12 | 1 MG
SDP

Supplier:  Medchemexpress LLC HY1035441MG

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[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-substance P is a synthetic peptide analog of Substance P bearing D-amino acid substitutions that alter receptor signaling. It is used in research to probe neuropeptide and chemokine receptor pharmacology, intracellular signaling pathways, and cellular responses in inflammation and cancer studies.

  • Acts as a biased agonist at neuropeptide and chemokine receptors.
  • Activates G12 and modulates ERK-2 and JNK signaling pathways.
  • Promotes neutrophil migration and intracellular Ca2+ mobilization.
  • Functions as a bombesin antagonist and shows activity in small cell lung cancer models.
  • Peptide sequence contains D-Arg, D-Phe, and D-Trp substitutions; molecular weight ≈ 1,516.83 g/mol.
  • Provided as a high-purity powder; store sealed, away from moisture, at -20°C to -80°C for long-term stability.

Catalog No. 50-002-48200


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