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Enzo Life Sciences N,N-Dimethylsphingosine, D-erythro (25 mg). CAS: 119567-63-4
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Supplier:  Enzo Life Sciences BMLSL1050025

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Potent and specific inhibitor of sphingosine kinase (IC50=5µM) which blocks conversion of sphingosine to sphingosine-1-phosphate (BML-SL140). Inhibitor of protein kinase C (PKC) which also stimulates Src-kinase. May affect expression of cell surface selectins, which in turn mediate leukocyte or tumor cell adhesion to endothelial cells and platelets. Induces apoptosis. Stereospecifically induces EGF receptor autophosphorylation producing EGF-like activity in vitro in the absence of EGF. Produced endogenously via ceramide catabolism. May be a target for neuropathic pain therapy. Alternative name: N,N-Dimethyl-D-erythro-sphingosine. Purity: ≥98% (TLC). Solubility: Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml). Long Term Storage: -20°C.

Catalog No. 50-201-2104


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