Medchemexpress LLC D(+)-Galactosamine hydrochloride | 1772-03-8 | 99.9% | 215.63 | 250 MG

Supplier:  Medchemexpress LLC 250MGHY42682R

D(+)-Galactosamine hydrochloride is an established experimental toxin that primarily causes liver injury by generating free radicals and depleting UTP nucleotides. It also induces renal dysfunction, with renal failure often associated with the end-stage of liver damage. This compound is a known animal model of fulminant hepatic failure when induced by lipopolysaccharide. In vitro, it induces apoptosis and necrosis in primary rat hepatocyte cultures, as well as caspase-3 activation and DNA fragmentation.

• Established experimental toxin for liver injury and renal dysfunction studies.
• Induces apoptosis and necrosis in primary rat hepatocyte cultures.
• Used in animal models of fulminant hepatic failure.
• Soluble in water (100 mg/mL) and DMSO (25 mg/mL).
• Suitable for in vivo administration using various formulations like PBS, PEG300, or corn oil.

Catalog No. 50-004-03280