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Medchemexpress LLC D-α-Hydroxyglutaric acid | 13095-47-1 | 148.11 | 10MG
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Supplier:  Medchemexpress LLC HY11303810MG

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D-α-Hydroxyglutaric acid is the primary metabolite accumulating in D-2-hydroxyglutaric aciduria, a neurometabolic disease. It acts as a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases. This compound also enhances reactive oxygen species (ROS) production, binds to and inhibits ATP synthase, and suppresses mTOR signaling. It accumulates in human cancers with specific mutations in IDH1 and IDH2 genes.

  • Primary metabolite in D-2-hydroxyglutaric aciduria
  • Weak competitive antagonist of α-ketoglutarate (α-KG)
  • Inhibits multiple α-KG-dependent dioxygenases
  • Increases reactive oxygen species (ROS) production
  • Binds and inhibits ATP synthase
  • Inhibits mTOR signaling
  • Accumulates in human cancers with IDH1 and IDH2 mutations

Catalog No. 50-004-38716


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