U-Blot Pan-D-Lactyllysine Rabbit pAb is a Rabbit-derived polyclonal antibody that specifically recognizes D-Lactyllysine a lysine lactylation modification at Lys(K) It shows reactivity with Species Independent Validated applications include WB IHC-P ICC/IF FC Recommended dilutions WB 11000 IHC-P 1100-1200 ICC/IF 1100-1200 FC 1100-1200 Purified by protein a D-Lactyllysine (KD-la) is the D-stereoisomer of lysine lactylation a novel type of lysine acylation post-translational modification By conjugating a D-lactyl group to lysine residues KD-la is mainly generated via non-enzymatic pathways from glycolysis byproducts and exists on both histone and non-histone proteins It participates in chromatin remodeling gene transcription and cellular metabolic stress responses and is closely associated with tumorigenesis inflammation metabolic reprogramming and other pathological processes serving as a key target in metabolic-epigenetic crosstalk research Supplied as 100 uL