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Cayman Chemical D-LysIn lactam 50mg

Supplier: Cayman Chemical 3168450 MG

A dual agonist of PPARa and PPARY binds to PPARa and PPARY (Kds 9 55 and 0 14 M respectively) increases transcriptional activity of PPARa and PPARY in a cell-based luciferase reporter assay at 10 M increases expression of PPARa PPARY and RXR as well as PPARa and PPARY target genes in HepG2 cells at 10 M increases glucose consumption as well as expression of GLUT2 and GLUT4 in HepG2 and 3T3-L1 cells respectively in a concentration-dependent manner decreases levels of glucose insulin free fatty acids triglycerides LDL ALT and AST in blood and reduces the size and number of hepatic lipid droplets in diabetic db/db mice at 20 mg/kg
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