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AdipoGen D-Sphingosine
Supplier: AdipoGen CDXD0559M025
Chemical. CAS 123-78-4. Formula C18H37NO2. MW BD9837. D-Sphingosine is a characteristic structural unit of many sphingolipids such as ceramides, gangliosides, globosides, sulfatides, sphingomyelin, and others. It is most abundant in nervous tissue and cell membranes. Sphingosine with an 18-carbon chain and a double bond at carbon 4 is the most abundant sphingosine in animal tissues. D-Sphingosine inhibits protein kinase C and phosphatidic acid phosphohydrolase, whereas it activates phospholipase D, diacylglycerol DAG kinase and the cation channel TRPM3. Phosphorylation of sphingosine by sphingosine kinases 1 and 2 SPHK 1, SPHK 2 produces sphingosine-1-phosphate, a potent bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization and morphogenesis.
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