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Apexbio Technology LLC D609 83373-60-8 5mg
SDP

Catalog No. 5000095701
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D609 (CAS 83373-60-8) is a selective and competitive inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC) with a reported Ki of 6 4 M By inhibiting PC-PLC D609 blocks the hydrolysis of phosphatidylcholine to diacylglycerol and phosphocholine processes implicated in cell signaling and proliferation D609 also inhibits sphingomyelin synthase and exhibits additional antioxidant properties due to its thiol group In cellular studies D609 reduces PC-PLC activity and cell proliferation in OVCAR3 and breast cancer cells and downregulates HER2 expression It also demonstrates anti-inflammatory effects in endothelial cells by suppressing inducible nitric oxide synthase and VCAM-1 gene expression D609 is widely used to investigate lipid-mediated signaling inflammation and cancer biology

Catalog No. 50-000-95701 Supplier Apexbio Technology LLC Supplier No. A33435
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D609 (CAS 83373-60-8) is a selective and competitive inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC) with a reported Ki of 6 4 M By inhibiting PC-PLC D609 blocks the hydrolysis of phosphatidylcholine to diacylglycerol and phosphocholine processes implicated in cell signaling and proliferation D609 also inhibits sphingomyelin synthase and exhibits additional antioxidant properties due to its thiol group In cellular studies D609 reduces PC-PLC activity and cell proliferation in OVCAR3 and breast cancer cells and downregulates HER2 expression It also demonstrates anti-inflammatory effects in endothelial cells by suppressing inducible nitric oxide synthase and VCAM-1 gene expression D609 is widely used to investigate lipid-mediated signaling inflammation and cancer biology

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