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CPC Scientific DABCYL-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-EDANS (trifluoroacetate salt) 0.5MG
SDP

Supplier:  CPC Scientific SUBS014A

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TACE FRET substrate I that is derived from the cleavage sequence of pro-TNFa recognized by the TNFa-cleaving enzyme (TACE). TNFa is presumably shed from cell membranes by TNFa-cleaving enzyme (TACE). Incubation of the TACE substrate with recombinant human TACE gives a specific cleavage to restore the quenched fluorescence. The substrate is widely used to screen inhibitors of TNF-convertase.ONE-LETTER SEQUENCE: Dabcyl-LAQAVRSSSR-EDANSMOLECULAR FORMULA: C70H104N22O18S1MOLECULAR WEIGHT:1573.80STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [396716-14-6], SYNONYMS: DABCYL-TNF--EDANS (-4 to +6) (human)RESEARCH AREA: ApoptosisREFERENCES: A.J. H.Gearing et al., Nature , 370, 555 (1994); K.M. Mohler et al., Nature , 370, 218 (1994); Becker BF, et al.Biol Chem 383, 1821-6 (2002); Mohler KM, et al., Nature 370, 218-20. (1994);

Catalog No. 50-211-0488


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