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Apexbio Technology LLC Dabigatran etexilate mesylate 872728-81-9 10mg
Supplier: Apexbio Technology LLC A334510
Dabigatran etexilate mesylate (CAS 872728-81-9) is an orally administered prodrug that upon conversion to dabigatran functions as a selective and reversible direct thrombin inhibitor In biochemical assays dabigatran exhibits high affinity for human thrombin (Ki 4 5 nM) and inhibits thrombin-induced platelet aggregation (IC50 10 nM) without affecting other platelet activators In vitro it induces concentration-dependent prolongation of coagulation parameters including aPTT PT and ECT in human plasma In vivo studies in rats and rhesus monkeys demonstrate dose-dependent anticoagulant activity following both intravenous and oral administration Dabigatran etexilate is utilized in research focused on coagulation disorders and anticoagulant mechanisms
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