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Cayman Chemical DabrafenIbmesylate 50mg
Supplier: Cayman Chemical 3525150 MG
An ATP-competitive Raf kinase inhibitor (IC50s = 0.64, 0.68, and 5 nM for wild-type B-RAF kinase, mutant B-RAFV600E, and wild-type C-RAF kinase, respectively); also inhibits ALK5, LIMK1, SIK2, PDK2, NEK11, CK1, and BRK (IC50s = 11, 15, 27, 57, 20, 41, and 79 nM, respectively) in a panel of 270 kinases at 300 nM; inhibits the growth of 16 cancer cell lines expressing mutant B-RAFV600E (GI50s = 50s = 50s = V600E-expressing A375P melanoma cells; reduces tumor growth in an A375P mouse xenograft model at 3-100 mg/kg
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