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Apexbio Technology LLC Dacarbazine 4342-03-4 200mg
Supplier: Apexbio Technology LLC A2197200
Dacarbazine (CAS 4342-03-4) is a triazene-based alkylating agent widely used in biomedical research and oncology Upon metabolic activation dacarbazine generates reactive methylating species that transfer methyl groups primarily to the O6 and N7 positions of guanine bases within DNA This alkylation promotes DNA strand cross-linking and mispairing ultimately inducing apoptosis in rapidly dividing cells Dacarbazine is commonly applied in studies modeling malignant melanoma Hodgkin lymphoma sarcoma and pancreatic islet cell carcinoma Its mechanism of DNA damage and cytotoxicity also informs research into chemoresistance and combination chemotherapy regimens
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