Dacarbazine

Description

CAS: 4342-03-4 | C6H10N6O | 182.19 g/mol

Used in treatment of malignant melanoma and sarcomas. Generates methyl adducts to purine bases in DNA

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

• Used in treatment of malignant melanoma and sarcomas
• Generates methyl adducts to purine bases in DNA

Specifications

Chemical Identifiers

• CAS: 4342-03-4
• MDL Number: MFCD00057167

• Melting Point: 210°C to 212°C
• Color: White to Yellow
• Molecular Formula: C4H3IN2O
• Quantity: 500 mg
• Merck Index: 14,2798
• Synonym: 5-iodopyrimidin-4-ol, 5-iodopyrimidin-4 3h-one, 4-hydroxy-5-iodopyrimidine, 5-iodo-1h-pyrimidin-4-one, 4 1h-pyrimidinone, 5-iodo, 5-iodopyrimidin-4 1h-one, 5-iodo-3h-pyrimidin-4-one, 5-iodo-3,4-dihydropyrimidin-4-one, 5-iodopyrimidin-4-ol;5-iodopyrimidin-4 1h-one
• Solubility Information: Slightly soluble in water,DMSO and ethanol /n
• InChI Key: SMIGOGPUTQXOKF-UHFFFAOYSA-N
• SMILES: C1=C(C(=O)NC=N1)I
• IUPAC Name: 5-iodo-1H-pyrimidin-6-one
• Molecular Weight (g/mol): 221.99
• PubChem CID: 12356582
• Formula Weight: 182.18
• Physical Form: Powder
• Chemical Name or Material: Dacarbazine

Safety and Handling

Hazard Category	H312+H332-H315-H319-H335-H350
Hazard Statement	GHS H Statement H311-H340-H350-H332-H315-H319-H335 Toxic in contact with skin. May cause genetic defects. May cause cancer. Harmful if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P201-P202-P261-P264b-P271-P280i-P281-P302+P352-P304+P340-P305+P351+P338-P308+P313-P312-P332+P313-P362-P501c
EINECSNumber	224-396-1
RTECSNumber	NI3950000
TSCA	No
Recommended Storage	Keep cold

SDS

RUO – Research Use Only