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Dacarbazine
Description
Used in treatment of malignant melanoma and sarcomas. Generates methyl adducts to purine bases in DNA
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
- Used in treatment of malignant melanoma and sarcomas
- Generates methyl adducts to purine bases in DNA
Specifications
Specifications
| Melting Point | 210°C to 212°C |
| Color | White to Yellow |
| Molecular Formula | C4H3IN2O |
| Quantity | 500 mg |
| Merck Index | 14,2798 |
| Synonym | 5-iodopyrimidin-4-ol, 5-iodopyrimidin-4 3h-one, 4-hydroxy-5-iodopyrimidine, 5-iodo-1h-pyrimidin-4-one, 4 1h-pyrimidinone, 5-iodo, 5-iodopyrimidin-4 1h-one, 5-iodo-3h-pyrimidin-4-one, 5-iodo-3,4-dihydropyrimidin-4-one, 5-iodopyrimidin-4-ol;5-iodopyrimidin-4 1h-one |
| Solubility Information | Slightly soluble in water,DMSO and ethanol /n |
| InChI Key | SMIGOGPUTQXOKF-UHFFFAOYSA-N |
| SMILES | C1=C(C(=O)NC=N1)I |
| IUPAC Name | 5-iodo-1H-pyrimidin-6-one |
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Safety and Handling
| Hazard Category | H312+H332-H315-H319-H335-H350 |
| Hazard Statement | GHS H Statement H311-H340-H350-H332-H315-H319-H335 Toxic in contact with skin. May cause genetic defects. May cause cancer. Harmful if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. |
| Precautionary Statement | P201-P202-P261-P264b-P271-P280i-P281-P302+P352-P304+P340-P305+P351+P338-P308+P313-P312-P332+P313-P362-P501c |
| EINECSNumber | 224-396-1 |
| RTECSNumber | NI3950000 |
| TSCA | No |
| Recommended Storage | Keep cold |
RUO – Research Use Only
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