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Medchemexpress LLC Dafadine-A | 1065506-69-5 | 98.9% | 391.46 | 1 ML
SDP

Catalog No. 5000394626
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Dafadine-A is a selective inhibitor of DAF-9 cytochrome P450 in the nematode *Caenorhabditis elegans*. It inhibits the mammalian ortholog of DAF-9 (CYP27A1) but does not inhibit DAF-12, or sterol- and oxysterol-metabolizing P450s. It is for research use only.

  • Induces a constitutive dauer formation (Daf-c) phenotype in more than 30% of wild-type *Caenorhabditis elegans* at 12.5 μM.
  • Causes a protruding vulva (Pvl) phenotype and distal-tip cell migration (Mig) defects in over 60% of wild-type *Caenorhabditis elegans* at 25 μM.
  • Inhibits the ability of CYP27A1 to metabolize 4-cholesten-3-one at 5 μM.
  • Extends the lifespan of wild-type *Caenorhabditis elegans* by 29%.
  • Dramatically inhibits cholesterol-induced melanoma spheroid propagation and downregulates Rap1A/Rap1B expression and phosphorylated AKT1-thr308/309 at 5-10 μM (48 h).
  • Significantly enhances Vemurafenib-induced apoptosis at 10 μM (48 h).

Catalog No. 50-003-94626 Supplier Medchemexpress LLC Supplier No. HY1667010MM/1ML
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Dafadine-A is a selective inhibitor of DAF-9 cytochrome P450 in the nematode *Caenorhabditis elegans*. It inhibits the mammalian ortholog of DAF-9 (CYP27A1) but does not inhibit DAF-12, or sterol- and oxysterol-metabolizing P450s. It is for research use only.

  • Induces a constitutive dauer formation (Daf-c) phenotype in more than 30% of wild-type *Caenorhabditis elegans* at 12.5 μM.
  • Causes a protruding vulva (Pvl) phenotype and distal-tip cell migration (Mig) defects in over 60% of wild-type *Caenorhabditis elegans* at 25 μM.
  • Inhibits the ability of CYP27A1 to metabolize 4-cholesten-3-one at 5 μM.
  • Extends the lifespan of wild-type *Caenorhabditis elegans* by 29%.
  • Dramatically inhibits cholesterol-induced melanoma spheroid propagation and downregulates Rap1A/Rap1B expression and phosphorylated AKT1-thr308/309 at 5-10 μM (48 h).
  • Significantly enhances Vemurafenib-induced apoptosis at 10 μM (48 h).

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