Apexbio Technology LLC DAMGO,5mg CAS# 78123-71-4

Supplier:  Apexbio Technology LLC B66215

DAMGO is a selective peptide agonist of the µ-opioid receptor (Ki = 1.18, 1430, and 213 nM for human µ-, δ-, and κ-opioid receptors, respectively) [1]. Opioid receptors are members of the class A family of G protein-coupled receptors (GPCRs), which transduce signals via heterotrimeric G proteins on the inner surface of the plasma membrane, leading to intracellular signaling cascades involved in many aspects of cellular function. Four opioid receptor types exist [μ, δ, κ, and opioid receptor-like 1 (ORL1)], among which the μ-opioid receptor has been most explored as its agonists are used to treat chronic pain [2]. In C6μ cell membranes, DAMGO at 10 µM produced a 250% stimulation of [35S]GTPγS binding above basal activity through the µ-opioid receptors, with an EC50 of 222 nM [2]. Other sizes are also available. Please inqury us for quote.

Catalog No. 50-224-0205