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Medchemexpress LLC Damgo tfa | 950492-85-0 | 99.5% | 627.61 | 1 ML
Supplier: Medchemexpress LLC HYP0210B10MM/1ML
DAMGO TFA is a selective μ-opioid receptor (μ-OPR) agonist, exhibiting a Kd of 3.46 nM for native μ-OPR. It significantly reduces the activation of neuronal Akt and ERK1/2 by CXCL12 and inhibits CXCL12-promoted neuronal survival without down-regulating CXCR4 protein expression. This compound also effectively inhibits the prostaglandin E2 (PGE2) induced increase in a tetrodotoxin-resistant voltage-gated Na+ current (TTX-R INa). In vivo studies show DAMGO TFA produces significant anti-injury and long-lasting analgesic effects in male Sprague-Dawley rats.
- Selective μ-opioid receptor agonist
- Exhibits Kd of 3.46 nM for native μ-OPR
- Reduces activation of neuronal Akt and ERK1/2
- Inhibits CXCL12-promoted neuronal survival
- Does not down-regulate CXCR4 protein expression
- Inhibits prostaglandin E2 induced increase in TTX-R INa
- Produces anti-injury effects
- Provides long-lasting analgesic effects
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