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Apexbio Technology LLC Danusertib (PHA-739358) 827318-97-8 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A41165.1
Danusertib (PHA-739358 CAS 827318-97-8) is a pyrrolopyrazole-based aminopyrazole derivative that functions as a pan-inhibitor of aurora kinases prominently targeting aurora B kinase (ABK) It also exhibits inhibitory activity against several other tyrosine kinases including the T315I mutant form RET TRK-A and fibroblast growth factor receptor-1 (FGFR-1) Due to its broad kinase inhibition profile danusertib has demonstrated significant antitumor activity in various xenograft spontaneous and genetically engineered animal models and is thus useful in oncology research involving leukemia and solid tumors
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