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Apexbio Technology LLC Dapagliflozin(Synonyms: Farxiga, Forxiga, BMS-512148, AZD-1656, Dapagliflozin propanediol, Dapagliflozin hydrate), 10mM (in 1mL DMSO), CAS: 461432-26-8.
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Supplier:  Apexbio Technology LLC A58545.1

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Dapagliflozin (CAS 461432-26-8) is a selective inhibitor of sodium-glucose cotransporter 2 (SGLT2) an integral membrane protein primarily expressed in renal proximal tubules Acting via specific inhibition of SGLT2-mediated glucose reabsorption dapagliflozin facilitates urinary glucose excretion thereby regulating plasma glucose levels It exhibits a potent EC50 of approximately 1 1 nM for human SGLT2 and shows over 1 200-fold selectivity for hSGLT2 over hSGLT1 in vitro Preclinical studies demonstrate improved glucose tolerance enhanced urinary glucose excretion and reduction of hyperglycemia in diabetic animal models Thus dapagliflozin serves as an important investigational molecule for type 2 diabetes research

Catalog No. 50-000-60684


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