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Medchemexpress LLC Daporinad (FK866) | 658084-64-1 | 99.9% | C24H29N3O2 | 1 ML
SDP

Catalog No. 5000358383
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Daporinad (FK866) is a non-competitive inhibitor of nicotinamide phosphoribosyltransferase (Nampt), with a Ki value of 0.3 nM. It depletes NAD+ and ATP levels, inhibits mTORC1 and MAPK/ERK pathways, and activates TFEB to induce autophagy. Daporinad causes the depletion of the endoplasmic reticulum Ca²⁺ pool, ultimately weakening the mitogen-induced Ca²⁺ signal and the activation and function of T cells. Daporinad induces cell cycle arrest and apoptosis, and inhibits cell proliferation. It can be used for the study of myeloma, liver cancer, and immunosuppression.

  • Non-competitive inhibitor of nicotinamide phosphoribosyltransferase (Nampt)
  • Depletes NAD+ and ATP levels
  • Inhibits mTORC1 and MAPK/ERK pathways
  • Activates TFEB to induce autophagy
  • Induces cell cycle arrest and apoptosis
  • Inhibits cell proliferation
  • Used for the study of myeloma, liver cancer, and immunosuppression

Catalog No. 50-003-58383 Supplier Medchemexpress LLC Supplier No. HY5087610MM/1ML
May include imposed supplier surcharges.
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Daporinad (FK866) is a non-competitive inhibitor of nicotinamide phosphoribosyltransferase (Nampt), with a Ki value of 0.3 nM. It depletes NAD+ and ATP levels, inhibits mTORC1 and MAPK/ERK pathways, and activates TFEB to induce autophagy. Daporinad causes the depletion of the endoplasmic reticulum Ca²⁺ pool, ultimately weakening the mitogen-induced Ca²⁺ signal and the activation and function of T cells. Daporinad induces cell cycle arrest and apoptosis, and inhibits cell proliferation. It can be used for the study of myeloma, liver cancer, and immunosuppression.

  • Non-competitive inhibitor of nicotinamide phosphoribosyltransferase (Nampt)
  • Depletes NAD+ and ATP levels
  • Inhibits mTORC1 and MAPK/ERK pathways
  • Activates TFEB to induce autophagy
  • Induces cell cycle arrest and apoptosis
  • Inhibits cell proliferation
  • Used for the study of myeloma, liver cancer, and immunosuppression

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