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Medchemexpress LLC DAPTA (D-Ala-peptide T-amide; Adaptavir) | 106362-34-9 | 98.9% | 856.88 | 5 MG
SDP

Catalog No. 5000425290
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DAPTA is a synthetic peptide that functions as a viral entry inhibitor by selectively targeting CCR5, exhibiting potent anti-HIV activities.

  • Inhibits HIV-1 replication in monocytes/macrophages by >90% at 1 nM.
  • Blocks HIV entry and prevents HIV-1 infection.
  • Reduces CCR5 mAb binding in human primary macrophages.
  • Potently blocks R5 gp120-mediated neuronal apoptosis.
  • More potent in preventing neuronal apoptosis than the CCR5 antagonist TAK-779.
  • Potently inhibits specific CD4-dependent binding of gp120 Bal (IC50 = 0.06 nM) and CM235 (IC50 = 0.32 nM) to CCR5.
  • Blocks formation of the gp120/sCD4 complex with CCR5 at 1 nM.
  • Inhibits the binding of gp120BaL/sCD4 to CCR5 (Cf2Th/synR5) cells with IC50 of 55 +/- 0.08 pM.

Catalog No. 50-004-25290 Supplier Medchemexpress LLC Supplier No. HYP10345MG
May include imposed supplier surcharges.
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DAPTA is a synthetic peptide that functions as a viral entry inhibitor by selectively targeting CCR5, exhibiting potent anti-HIV activities.

  • Inhibits HIV-1 replication in monocytes/macrophages by >90% at 1 nM.
  • Blocks HIV entry and prevents HIV-1 infection.
  • Reduces CCR5 mAb binding in human primary macrophages.
  • Potently blocks R5 gp120-mediated neuronal apoptosis.
  • More potent in preventing neuronal apoptosis than the CCR5 antagonist TAK-779.
  • Potently inhibits specific CD4-dependent binding of gp120 Bal (IC50 = 0.06 nM) and CM235 (IC50 = 0.32 nM) to CCR5.
  • Blocks formation of the gp120/sCD4 complex with CCR5 at 1 nM.
  • Inhibits the binding of gp120BaL/sCD4 to CCR5 (Cf2Th/synR5) cells with IC50 of 55 +/- 0.08 pM.

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