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Apexbio Technology LLC Darapladib(Synonyms: SB-480848, Darapladib, LP-PLA2 inhibitor, SB480848), 10mM (in 1mL DMSO), CAS: A3349.
Supplier: Apexbio Technology LLC A33495.1
Darapladib (CAS 356057-34-6) is a selective inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2) an enzyme strongly implicated in the progression and instability of atherosclerotic plaques In vitro Darapladib shows high potency toward Lp-PLA2 (IC50 approximately 270 pM) with minimal inhibition of other secretory PLA2 isoforms (e g III V X) Preclinical studies in ApoE-deficient mouse models demonstrate that inhibition of Lp-PLA2 attenuates vascular inflammatory processes and markedly reduces atherosclerotic lesion formation Clinically Darapladib administration in statin-treated patients significantly decreases plasma Lp-PLA2 activity and inflammatory markers indicating potential applications in cardiovascular research related to atherosclerosis and associated inflammation
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