Apexbio Technology LLC Darifenacin HBr 133099-07-7 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC B16005.1

Darifenacin HBr (CAS 133099-07-7) known as UK88525 is a selective antagonist of the M3 muscarinic acetylcholine receptor (mAChR M3) It demonstrates high binding affinity (pKi 8 9) toward M3 receptors which mediate smooth muscle contraction and glandular secretion in various tissues In vitro studies reveal that darifenacin acts as a substrate of the P-gp efflux transporter at the blood-brain and blood-ocular barriers In animal models darifenacin modulates bladder contractility and reduces bladder afferent nerve activity Clinically it is employed in research focusing on disorders involving abnormal detrusor muscle activity such as overactive bladder syndrome

Catalog No. 50-000-63757