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Medchemexpress LLC Darifenacin hydrobromide | 133099-07-7 | 99.8% | C28H31BrN2O2 | 5 MG
Supplier: Medchemexpress LLC HYA00125MG
Darifenacin hydrobromide is a selective and orally active M3 muscarinic receptor (M3R) antagonist. It is used in the study of urinary incontinence and other symptoms of overactive bladder, and has demonstrated anti-tumor effects by inhibiting tumor growth in colorectal cancer cells. In vitro, it inhibits Kv currents and the phosphorylation of p38, ERK1/2, and Akt. In vivo studies showed antitumor effects in xenograft mouse models and decreased afferent activity in rat bladders.
- Selective and orally active M3 muscarinic receptor antagonist
- Used in the study of urinary incontinence and overactive bladder symptoms
- Exhibits anti-tumor effects in colorectal cancer cells
- Inhibits Kv currents in coronary arterial smooth muscle cells
- Decreases afferent activity of bladder Aδ and C fibers in female rats
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