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Medchemexpress LLC Darizmetinib | 2369583-33-3 | C21H17F2N5O3S | 250 MG
Supplier: Medchemexpress LLC 250MGHY152860
Darizmetinib is an orally active, potent, and selective inhibitor of mitogen-activated protein kinase kinase 4 (MKK4; MAP2K4). It selectively targets, binds to, and inhibits the activity of MKK4 in liver cells. This inhibition enhances MKK7 and JNK1 signaling pathways, activating transcription factors ATF2 and ELK1, which promotes cell proliferation and liver regeneration. Darizmetinib is promising for research to prevent liver failure after extensive oncological liver resections or transplantation of small liver grafts.
- Orally active, potent, and selective MKK4 inhibitor
- Enhances MKK7 and JNK1 signaling pathways
- Activates transcription factors ATF2 and ELK1
- Promotes hepatocyte proliferation and survival
- Aids liver regeneration following hepatectomy
- Potential to prevent liver failure and restore liver mass
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