Medchemexpress LLC Darunavir Ethanolate | 635728-49-3 | 99.9% | 593.73 | 100 MG

Supplier:  Medchemexpress LLC HY17041100MG

Darunavir ethanolate (TMC114 Ethanolate) is a potent HIV protease inhibitor used to treat and prevent HIV/AIDS. Darunavir has a Ki of 1 nM for wild type HIV-1 protease. It is for research use only and not sold to patients. Darunavir is effective against wild-type and PI-resistant HIV, and has an oral bioavailability of 37%. It needs to be combined with ritonavir, which increases the bioavailability to 82%.

• Potent HIV protease inhibitor
• Active against HIV-1 clinical isolates
• Forms hydrogen bonds with conserved main-chain atoms of Asp29 and Asp30 of the protease
• Greater potency than saquinavir, amprenavir, nelfinavir, indinavir, lopinavir, and ritonavir in an in vitro study
• Effective against wild-type and PI-resistant HIV
• Oral bioavailability increased to 82% when combined with ritonavir

Catalog No. 50-003-84959