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Medchemexpress LLC Dazostinag disodium | 2553413-93-5 | 98.7% | 754.48 | 500 UG
Supplier: Medchemexpress LLC HY148029500UG
Dazostinag disodium (TAK-676) is a STING agonist that activates the STING signaling pathway and type I interferons. It acts as a modulator of the immune system, leading to complete regressions and durable memory T-cell immunity, and promotes durable IFN-dependent antitumor immunity.
- Activates the STING-TBK1-IRF3 pathway
- Exerts in vitro immune cell activation in mouse BM-derived dendritic cells
- Promotes activation of dendritic cells, natural killer cells, and T cells
- Well tolerated and shows dose-proportional pharmacokinetics in plasma
- Exhibits anti-tumor function in syngeneic tumors in mice
- Induces dose-dependent cytokine responses, increasing activation and proliferation of immune cells
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