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Medchemexpress LLC Dbco-nhco-peg5-nhs ester | 1378531-80-6 | C36H43N3O11 | 1 MG
Supplier: Medchemexpress LLC HY1402751MG
DBCO-NHCO-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring a DBCO group capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules that contain azide groups. PROTACs consist of two different ligands connected by a linker, where one ligand targets an E3 ubiquitin ligase and the other targets a specific protein, exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains a DBCO group for SPAAC
- Exploits intracellular ubiquitin-proteasome system
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