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Medchemexpress LLC Dbco-peg2-val-cit-pab-mmae | 2845934-59-8 | 99.3% | 1569.92 g/mol | C84H120N12O17 | 25 MG
SDP

Supplier:  Medchemexpress LLC HY17228725MG

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A cleavable ADC linker composed of a DBCO reactive handle, a PEG2 spacer, a cathepsin-cleavable valine-citrulline dipeptide with a para-aminobenzyl (PAB) self-immolative spacer, and the cytotoxic MMAE payload. Designed for conjugation via strain-promoted alkyne-azide cycloaddition (SPAAC) to form antibody-drug conjugates.

  • High purity suitable for conjugation reactions.
  • Cleavable val-cit dipeptide enables payload release in lysosomes.
  • Dbco moiety supports copper-free click conjugation (SPAAC).
  • Peg2 spacer improves solubility and linker flexibility.
  • Available in small mg-scale quantities for synthesis and development.

Catalog No. 50-002-02869


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