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Medchemexpress LLC Dbco-(peg2-vc-pab-mmae)2 | 2259318-55-1 | 99.2% | 2835.50 g·mol⁻¹ | C149H224N22O32 | 10 MG
SDP

Catalog No. 5000204160
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DBCO-(PEG2-VC-PAB-MMAE)2 is a click-chemistry compatible ADC linker dimer that carries monomethyl auristatin E (MMAE) payloads on a cleavable Val-Cit-PAB spacer and features a DBCO handle for strain-promoted alkyne-azide cycloaddition (SPAAC). It is used for bioconjugation and synthesis of antibody-drug conjugates, enabling controlled intracellular release of MMAE via protease cleavage.

  • Enables strain-promoted alkyne-azide cycloaddition for copper-free bioconjugation.
  • Includes a Val-Cit-PAB protease-cleavable linker for intracellular payload release.
  • Delivers MMAE warheads for potent tubulin inhibition after release.
  • Available as a powder with multiple package sizes for research-scale synthesis.
  • High supplied purity supports reliable conjugation and analytical characterization.

Catalog No. 50-002-04160 Supplier Medchemexpress LLC Supplier No. HY12669010MG
May include imposed supplier surcharges.
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DBCO-(PEG2-VC-PAB-MMAE)2 is a click-chemistry compatible ADC linker dimer that carries monomethyl auristatin E (MMAE) payloads on a cleavable Val-Cit-PAB spacer and features a DBCO handle for strain-promoted alkyne-azide cycloaddition (SPAAC). It is used for bioconjugation and synthesis of antibody-drug conjugates, enabling controlled intracellular release of MMAE via protease cleavage.

  • Enables strain-promoted alkyne-azide cycloaddition for copper-free bioconjugation.
  • Includes a Val-Cit-PAB protease-cleavable linker for intracellular payload release.
  • Delivers MMAE warheads for potent tubulin inhibition after release.
  • Available as a powder with multiple package sizes for research-scale synthesis.
  • High supplied purity supports reliable conjugation and analytical characterization.

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