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Medchemexpress LLC Dbco-PEG3-VC-Exatecan | 2754384-70-6 | 96.7% | 1331.44 g/mol | C71H79FN10O15 | 10 MG
Supplier: Medchemexpress LLC HY16479210MG
DBCO-PEG3-VC-Exatecan is a drug-linker conjugate used in antibody-drug conjugate (ADC) research that couples a DBCO-functionalized PEG3 valine-citrulline cleavable linker to the topoisomerase I inhibitor exatecan.
- Provides a cleavable valine-citrulline (VC) linker for intracellular release.
- Includes a DBCO handle for strain-promoted azide-alkyne cycloaddition (click chemistry).
- Incorporates a PEG3 spacer to improve solubility and linker flexibility.
- Delivers exatecan, a DNA topoisomerase I inhibitor payload.
- High purity (~96.7%) and large molecular weight (~1331.44 g/mol).
- Soluble in DMSO at 50 mg/mL with ultrasonic assistance.
- Stored sealed at -20 °C; in solution, stable at -80 °C for 6 months and -20 °C for 1 month.
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