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Medchemexpress LLC Dbco-PEG3-VC-Exatecan | 2754384-70-6 | 96.7% | 1331.44 g/mol | C71H79FN10O15 | 10 MG
SDP

Catalog No. 5000204241
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DBCO-PEG3-VC-Exatecan is a drug-linker conjugate used in antibody-drug conjugate (ADC) research that couples a DBCO-functionalized PEG3 valine-citrulline cleavable linker to the topoisomerase I inhibitor exatecan.

  • Provides a cleavable valine-citrulline (VC) linker for intracellular release.
  • Includes a DBCO handle for strain-promoted azide-alkyne cycloaddition (click chemistry).
  • Incorporates a PEG3 spacer to improve solubility and linker flexibility.
  • Delivers exatecan, a DNA topoisomerase I inhibitor payload.
  • High purity (~96.7%) and large molecular weight (~1331.44 g/mol).
  • Soluble in DMSO at 50 mg/mL with ultrasonic assistance.
  • Stored sealed at -20 °C; in solution, stable at -80 °C for 6 months and -20 °C for 1 month.

Catalog No. 50-002-04241 Supplier Medchemexpress LLC Supplier No. HY16479210MG
May include imposed supplier surcharges.
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DBCO-PEG3-VC-Exatecan is a drug-linker conjugate used in antibody-drug conjugate (ADC) research that couples a DBCO-functionalized PEG3 valine-citrulline cleavable linker to the topoisomerase I inhibitor exatecan.

  • Provides a cleavable valine-citrulline (VC) linker for intracellular release.
  • Includes a DBCO handle for strain-promoted azide-alkyne cycloaddition (click chemistry).
  • Incorporates a PEG3 spacer to improve solubility and linker flexibility.
  • Delivers exatecan, a DNA topoisomerase I inhibitor payload.
  • High purity (~96.7%) and large molecular weight (~1331.44 g/mol).
  • Soluble in DMSO at 50 mg/mL with ultrasonic assistance.
  • Stored sealed at -20 °C; in solution, stable at -80 °C for 6 months and -20 °C for 1 month.

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