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Medchemexpress LLC Dbco-peg4-val-cit-pab-mmaf | 2244602-23-9 | 98.7% | 1672.01 g/mol | C88H126N12O20 | 5 MG
SDP

Catalog No. 5000203365
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DBCO-PEG4-Val-Cit-PAB-MMAF is a cleavable linker-payload conjugate used for antibody-drug conjugate synthesis and bioconjugation. The construct combines a DBCO bioorthogonal handle, a PEG4 spacer, a cathepsin-cleavable valine-citrulline dipeptide with a PAB self-immolative spacer, and an MMAF cytotoxic payload. Analytical documentation and handling instructions are available.

  • Enables strain-promoted alkyne-azide cycloaddition (SPAAC) via DBCO for click chemistry.
  • Peg4 spacer increases hydrophilicity and reduces aggregation.
  • Val-Cit dipeptide is cleavable by cathepsin enzymes for controlled payload release.
  • PAB self-immolative spacer allows rapid payload liberation after cleavage.
  • Contains MMAF, a tubulin inhibitor payload for ADC applications.
  • High reported purity with supporting analytical data and safety documentation.

Catalog No. 50-002-03365 Supplier Medchemexpress LLC Supplier No. HY1309905MG
May include imposed supplier surcharges.
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DBCO-PEG4-Val-Cit-PAB-MMAF is a cleavable linker-payload conjugate used for antibody-drug conjugate synthesis and bioconjugation. The construct combines a DBCO bioorthogonal handle, a PEG4 spacer, a cathepsin-cleavable valine-citrulline dipeptide with a PAB self-immolative spacer, and an MMAF cytotoxic payload. Analytical documentation and handling instructions are available.

  • Enables strain-promoted alkyne-azide cycloaddition (SPAAC) via DBCO for click chemistry.
  • Peg4 spacer increases hydrophilicity and reduces aggregation.
  • Val-Cit dipeptide is cleavable by cathepsin enzymes for controlled payload release.
  • PAB self-immolative spacer allows rapid payload liberation after cleavage.
  • Contains MMAF, a tubulin inhibitor payload for ADC applications.
  • High reported purity with supporting analytical data and safety documentation.

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