Medchemexpress LLC Dbco-peg4-val-cit-pab-mmaf | 2244602-23-9 | 98.7% | 1672.01 g/mol | C88H126N12O20 | 5 MG

Supplier:  Medchemexpress LLC HY1309905MG

DBCO-PEG4-Val-Cit-PAB-MMAF is a cleavable linker-payload conjugate used for antibody-drug conjugate synthesis and bioconjugation. The construct combines a DBCO bioorthogonal handle, a PEG4 spacer, a cathepsin-cleavable valine-citrulline dipeptide with a PAB self-immolative spacer, and an MMAF cytotoxic payload. Analytical documentation and handling instructions are available.

• Enables strain-promoted alkyne-azide cycloaddition (SPAAC) via DBCO for click chemistry.
• Peg4 spacer increases hydrophilicity and reduces aggregation.
• Val-Cit dipeptide is cleavable by cathepsin enzymes for controlled payload release.
• PAB self-immolative spacer allows rapid payload liberation after cleavage.
• Contains MMAF, a tubulin inhibitor payload for ADC applications.
• High reported purity with supporting analytical data and safety documentation.

Catalog No. 50-002-03365