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Medchemexpress LLC DBCO-PEG4-Val-Cit-PAB-PNP | 2226472-28-0 | 97.3% | 1079.16 | C55H66N8O15 | 50 MG
Supplier: Medchemexpress LLC HYW19091350MG
DBCO-PEG4-Val-Cit-PAB-PNP is a cleavable antibody-drug conjugate (ADC) linker for bioconjugation and click-chemistry applications. It combines a dibenzocyclooctyne (DBCO) moiety for copper-free SPAAC conjugation with a PEG4 spacer for solubility and flexibility, a Val-Cit protease-cleavable dipeptide linked to a PAB self-immolative spacer, and a PNP leaving group for amine-mediated payload attachment.
- Contains DBCO for copper-free strain-promoted azide-alkyne cycloaddition.
- Includes PEG4 spacer to improve solubility and reduce steric hindrance.
- Features Val-Cit dipeptide cleavable by cathepsin B for selective payload release.
- Incorporates a PAB self-immolative spacer to enable rapid payload liberation after cleavage.
- Provides a PNP leaving group for straightforward amine coupling of payloads.
- Suited for synthesis of ADCs and conjugation to azide-bearing molecules.
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