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Apexbio Technology LLC DBeQ 177355-84-9 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A86295.1
DBeQ (CAS 177355-84-9) is a selective and reversible inhibitor of the ATPase p97 (also known as VCP or Cdc48 in yeast) exhibiting an IC50 value of approximately 1 5 M p97 is an essential abundantly expressed hexameric AAA ATPase implicated in multiple cellular processes including endoplasmic reticulum-associated degradation (ERAD) mitochondrial-associated degradation autophagy maturation and regulation of transcription factors DBeQ inhibits p97 by specifically targeting its D1 and D2 ATPase domains leading to blockage of ERAD and autophagosome maturation Research applications of DBeQ include investigating protein homeostasis cancer biology and apoptosis induction mediated through caspases-3 and -9 activation
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