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Medchemexpress LLC DC-LC3in-D5 | 2868312-73-4 | 98.6% | C19H22Cl2N2O3 | 10 MM 1 ML
Supplier: Medchemexpress LLC HY14188210MM/1ML
DC-LC3in-D5 is an autophagy inhibitor that functions by attenuating LC3B lipidation. It binds with LC3B and disrupts the LC3B-LBP2 interaction with an IC50 of 200 nM. This compound may be useful in anti-HCV or combination cancer research through its autophagy-inhibiting properties.
- Attenuates LC3B lipidation
- Disrupts LC3B-LBP2 interaction
- Demonstrates high selectivity to LC3A/B in proteome
- Exhibits potent covalent reactivity and selectivity to LC3A/B in HeLa cells
- Inhibits autophagic vesicle formation
- Leads to accumulation of p62
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