Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 5000355357

Medchemexpress LLC DC-LC3in-D5 | 2868312-73-4 | 98.6% | C19H22Cl2N2O3 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY141882100MG

Encompass_Preferred

DC-LC3in-D5 is an autophagy inhibitor that attenuates LC3B lipidation by binding with LC3B and disrupting the LC3B-LBP2 interaction with an IC50 of 200 nM. This compound demonstrates high selectivity to LC3A/B in the proteome and exhibits potent covalent reactivity and selectivity to LC3A/B in HeLa cells. It may contribute to anti-HCV or combination research in cancer through inhibiting autophagy.

  • Acts as an autophagy inhibitor by attenuating LC3B lipidation
  • Binds with LC3B and disrupts the LC3B-LBP2 interaction
  • Demonstrates high selectivity to LC3A/B in the proteome
  • Exhibits potent covalent reactivity and selectivity to LC3A/B in HeLa cells
  • Treatment of HeLa cells with 3-30 μM results in disruption of LC3B lipidation, inhibition of autophagic vesicle formation, and accumulation of p62

Catalog No. 50-003-55357


May include imposed supplier surcharges.
Only null left
Add to Cart

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.