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Medchemexpress LLC DC-LC3in-D5 | 2868312-73-4 | 98.6% | C19H22Cl2N2O3 | 25 MG
Supplier: Medchemexpress LLC 25MGHY141882
DC-LC3in-D5 is an autophagy inhibitor that functions by attenuating LC3B lipidation. It directly binds with LC3B and disrupts the interaction between LC3B and LBP2 with an IC50 of 200 nM. This compound has potential applications in anti-HCV (Hepatitis C Virus) research and combination therapies for cancer, owing to its autophagy-inhibiting properties.
- Attenuates LC3B lipidation
- Binds with LC3B and disrupts LC3B-LBP2 interaction
- Exhibits an IC50 of 200 nM for disrupting LC3B-LBP2 interaction
- May contribute to anti-HCV or combination research in cancer
- Available at 98.62% purity
- Demonstrates high selectivity to LC3A/B in the proteome
- Exhibits potent covalent reactivity and selectivity to LC3A/B in HeLa cells
- Disruption of LC3B lipidation, inhibition of autophagic vesicle formation, and accumulation of p62 in HeLa cells
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