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Medchemexpress LLC DCC-3116 | 2543673-19-2 | 99.7% | 535.60 | 100 MG
Supplier: Medchemexpress LLC HY160699100MG
DCC-3116 is an orally active ULK1/2 inhibitor. It can inhibit autophagy in lung cancer cells by inhibiting KRASG12C signaling, thereby inhibiting the proliferation of lung cancer cells and exerting anti-cancer effects.
- It is an orally active ULK1/2 inhibitor.
- It inhibits autophagy in lung cancer cells by inhibiting KRASG12C signaling.
- It inhibits the proliferation of lung cancer cells and exerts anti-cancer effects.
- It inhibits the proliferation of NCI-H2122 and Calu-1 cells, decreases the expression of pS318-ATG13, and has a synergistic effect when combined with Sotorasib.
- It inhibits tumor growth in mouse models of NSCLC lung cancer and improves mouse survival rate, while significantly reducing mouse body weight (>20%).
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