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Medchemexpress LLC DCZ0415 | 2242470-43-3 | 99.8% | 200 MG
SDP

Catalog No. 5000341088
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DCZ0415 is a potent TRIP13 inhibitor that impairs nonhomologous end joining repair and inhibits NF-κB activity. It induces anti-myeloma activity in vitro, in vivo, and in primary cells derived from drug-resistant myeloma patients.

  • Significantly decreases colony formation
  • Inhibits cell proliferation
  • Decreases viability in MM cells
  • Induces apoptotic cell death
  • Causes accumulation of MM cells in G0/G1 phase
  • Decreases protein levels of phosphorylated iκBα and NF-κB
  • Exerts cytotoxic effects by inhibiting DNA synthesis
  • Reduces growth of MM cells-induced tumors in immune-deficient mice

Catalog No. 50-003-41088 Supplier Medchemexpress LLC Supplier No. HY130603200MG
May include imposed supplier surcharges.
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DCZ0415 is a potent TRIP13 inhibitor that impairs nonhomologous end joining repair and inhibits NF-κB activity. It induces anti-myeloma activity in vitro, in vivo, and in primary cells derived from drug-resistant myeloma patients.

  • Significantly decreases colony formation
  • Inhibits cell proliferation
  • Decreases viability in MM cells
  • Induces apoptotic cell death
  • Causes accumulation of MM cells in G0/G1 phase
  • Decreases protein levels of phosphorylated iκBα and NF-κB
  • Exerts cytotoxic effects by inhibiting DNA synthesis
  • Reduces growth of MM cells-induced tumors in immune-deficient mice

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