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Medchemexpress LLC DDP-38003 dihydrochloride | 1831167-98-6 | 99.3% | 423.38 | 50 MG
Supplier: Medchemexpress LLC HY19612A50MG
DDP-38003 dihydrochloride is a novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC50 of 84 nM. It demonstrates significant in vitro and in vivo efficacy, inhibiting KDM1A and reducing colony forming ability in THP-1 cells. In mouse leukemia models, oral administration of DDP-38003 dihydrochloride led to increased survival.
- Inhibits histone lysine-specific demethylase 1A (KDM1A/LSD1)
- Orally available
- IC50 of 84 nM for KDM1A
- Reduces colony forming ability and induces differentiation of THP-1 cells
- Shows in vivo efficacy in mouse leukemia models
- Potential oral anticancer agent
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