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Medchemexpress LLC DDP-38003 trihydrochloride | 2319789-94-9 | 98.0% | 459.84 | 1 MG
SDP

Catalog No. 5000400599
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DDP-38003 trihydrochloride is a novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC50 of 84 nM. It exhibits in vivo efficacy after oral administration, leading to increased survival in mouse leukemia models with evidence of KDM1A inhibition. It is considered a potential oral anticancer agent.

  • Novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1)
  • IC50 of 84 nM against KDM1A
  • More active in reducing colony-forming ability and inducing differentiation of THP-1 cells compared to the 1R, 2S analogue
  • Exhibits in vivo efficacy after oral administration
  • Increases survival in mouse leukemia models (62% increase)
  • Half-life of 8 hours
  • Potential oral anticancer agent

Catalog No. 50-004-00599 Supplier Medchemexpress LLC Supplier No. HY19612B1MG
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DDP-38003 trihydrochloride is a novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC50 of 84 nM. It exhibits in vivo efficacy after oral administration, leading to increased survival in mouse leukemia models with evidence of KDM1A inhibition. It is considered a potential oral anticancer agent.

  • Novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1)
  • IC50 of 84 nM against KDM1A
  • More active in reducing colony-forming ability and inducing differentiation of THP-1 cells compared to the 1R, 2S analogue
  • Exhibits in vivo efficacy after oral administration
  • Increases survival in mouse leukemia models (62% increase)
  • Half-life of 8 hours
  • Potential oral anticancer agent

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