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ABclonal Technology DDX3X/DDX3Y Rabbit mAb
Supplier: ABclonal Technology A2379420UL
The protein encoded by this gene is a member of the DEAD-box RNA helicase family defined by the Asp-Glu-Ala-Asp (DEAD) motif with ATP-dependent RNA helicase and RNA-independent ATPase activities Unlike most DEAD-box helicases its ATPase activity is stimulated by both RNA and DNA It plays roles in the nucleus (transcriptional regulation mRNP assembly pre-mRNA splicing and mRNA export) and cytoplasm (translation cellular signaling and viral replication) Misregulation is linked to tumorigenesis This gene has a paralog on the Y chromosome and pseudogenes on chromosomes 4 and X Mutations can cause male infertility reduced germ cell numbers and Sertoli-cell only syndrome Alternative splicing generates multiple isoforms
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