Apexbio Technology LLC Deacetylase Inhibitor Cocktail (100X in 70% DMSO) 100x1ml

Supplier:  Apexbio Technology LLC K1017100

Deacetylase Inhibitor Cocktail is composed of several compounds that act synergistically to maintain the acetylation status of molecules The balance between acetyltransferase and deacetylase activities impacts chromatin compaction transcription factor activity and protein aggregation and the variations of these modifications have garnered considerable interest from researchers Our product Deacetylase Inhibitor Cocktail is a valuable tool for investigating these changes The Deacetylation Inhibition Cocktail includes four active components 40 M Trichostatin A 1 mM EX-527 400 mM nicotinamide and 200 mM sodium butyrate These compounds are dissolved in 70% DMSO each with distinct specific actions Trichostatin A inhibits class I/II HDACs EX-527 selectively inhibits SIRT1 with weaker activity against SIRT2 and SIRT3 Nicotinamide acts as an inhibitor of sirtuins (SIRT1-7 class III HDACs) Sodium butyrate competitively inhibits class I/II HDACs

Catalog No. 50-310-7273