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CPC Scientific Decy-Arg-Val-Lys-Arg-CMK (trifluoroacetate salt) 25MG
Supplier: CPC Scientific CASP089D
Peptidyl chloromethylketone that binds to the catalytic site of furin and thus inhibits cleavage and fusion activity of viral glycoproteins, as well as virus replication. This compound also decreases the production of b-amyloid-induced active matrix metalloproteinase 2 in U87 cells. Furthermore, other than furin N-1505 the protein also inhibited the proprotein convertases PC7/LPC, PACE4, and PC6 (W.Garten, personal communication).SEQUENCE: Decy-Arg-Val-Lys-Arg-CMK (trifluoroacetate salt)ONE-LETTER SEQUENCE: Decy-RVKR-CMKMOLECULAR FORMULA: C34H66Cl1N11O5MOLECULAR WEIGHT: 744.4STORAGE CONDITIONS: -20 5 CCAS REGISTRY NUMBER: [150113-99-8]SYNONYMS: Furin Inhibitor I, Dec-RVKR-CMK, Furin Convertase Inhibitor (Chloromethylketone)RESEARCH AREA: ApoptosisREFERENCES:W.Garten et al., Virology, 172, 25 (1989)A.Stieneke-Grber et al., EMBO J., 11, 2407 (1992)S.Hallenberger et al., Nature, 360, 358 (1992)W.Garten et al., Biochimie, 76, 217 (1994)J.-B.Denault et al., FEBS
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