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Edvotek™ Decoding Fragile X Syndrome
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Catalog No. S001437 Shop All EDVOTEK Products
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10 Lab Groups
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Catalog No. Class Size
S001437 10 Lab Groups
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Catalog No. S001437 Supplier Edvotek™ Supplier No. S55
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Description

In this kit, students gain an understanding of the screening process for Fragile X syndrome. Students will analyze simulated patient PCR samples to determine CGG repeat expansions in the FMR1 gene. Next, simulated Southern blot analysis will be used to confirm repeat size and methylation status.

  • Students will explore how CGG repeat expansions in the FMR1 gene cause Fragile X Syndrome, including the differences between normal, gray zone, premutation, and full mutation alleles
  • Gain hands-on experience preparing and running an agarose gel to separate simulated patient PCR samples, then interpret fluorescent band patterns to estimate CGG repeat counts and infer a patient's genetic sex
  • Learn how polymerase chain reaction amplifies specific regions of DNA to screen for Fragile X carrier status, and understand the limitations of PCR when it comes to detecting large, full-mutation expansions
  • Analyze simulated Southern blot results to detect large CGG repeat expansions and assess FMR1 gene methylation status
  • Group size: For 10 Lab Groups
  • Kit includes: Instructions, Ready-to-Load QuickStrip™ Dye Samples, UltraSpec-Agarose™, Electrophoresis Buffer (50X), Practice Gel Loading Solution, Disposable Pipets
  • All you need: DNA Electrophoresis Apparatus and Power Supply, Micropipettes: 5-50 μL (Optional), Blue Light Transilluminator, Microwave or Hot Plate
  • Storage: Room Temperature Stable. Storage of Ready-to-Load QuickStrip™ samples in the Refrigerator is Recommended

Specifications

Grade Level High School, Higher Ed
Class Size 10 Lab Groups
Product Type DNA Fingerprinting By Southern Blot
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