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Medchemexpress LLC Decursinol angelate | 130848-06-5 | 5 MG
Supplier: Medchemexpress LLC HYN43225MG
Decursinol angelate acts as a PKC activator and GDH inhibitor, with an IC50 of 1.432 μM against human GDH. It activates PKC, downregulates PKCα and PKCβII isoforms, and exhibits cytotoxic activity against cancer cells. Decursinol angelate also inhibits VEGF-induced autophosphorylation of VEGFR2, downstream p42/44 ERK and JNK-MAPK signaling pathways, and the angiogenesis process. It is applicable to research related to cancer and leukemia.
- Potent PKC activator
- Inhibits human glutamate dehydrogenase (IC50 1.432 μM)
- Exhibits cytotoxic activity against various human cancer cell lines
- Inhibits VEGF-induced angiogenesis
- Modulates macrophage polarization through NFκB and MAPK pathways
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